Some time after my brother was diagnosed with leukemia I created a Doom mod with the premise being that you would fight cancer. I didn't get all that far: The fist became a syringe, the BFG became a bottle of Nystatin
and a hospital computer monitor was thrown in. A separate file replaced the Doom-guy with my brother's face. I wrote a readme at the time, although I believe the only place that I released this was on my first website, which I made shortly after this project.